The relation of infection to traditional antibiotics
Can CBD be useful for battling resistant bacterial strains? Findings from Australia’s University of Queensland say this could be. But it helps to consider the changing relationship between bacteria and antibiotics before we take a close look at the research.
Antibiotics have been an important tool in the fight against bacteria and diseases, since Alexander Fleming’s pioneering discovery of penicillin in 1928. So while we are still using the same techniques that were tried and tested today, bacteria have developed. Some bacteria, fungi, and parasites are able to adapt and nullify the effectiveness of the medication by forming a resistance when exposed to antibiotics.
It is worth remembering that resistance to antimicrobials was likely to occur anyway, as the bacteria’s genetic code changes over time. However, antibiotic overuse is thought to be a major factor driving the growth of resistant strains.
Antimicrobial resistance, according to the World Health Organisation, “is an extremely severe challenge to global public health, requiring action in all sectors of government and society.” This has driven researchers off the beaten track as they attempt to classify compounds which may be useful in supporting the fight against harmful bacteria. The cannabidiol (CBD), a cannabinoid found in Cannabis sativa, is one such compound invoked.
Researchers try new ways of treating pathogens and resistant bacteria
CBD was found to be effective against gramme-positive bacteria by Dr. Mark Blaskovich, Principal Investigator and Program Director for the Society for Open Antimicrobial Drug Discovery, and Senior Research Officer at the Institute for Molecular Bioscience at Queensland University. Gram-positive bacterial strains include Staphylococcus aureus (common for infections of the skin) and Streptococcus pneumoniae (common in bacterial pneumonia).
Dr. Blaskovich presented his results to the American Society for Microbiology at its annual meeting. Synthetic CBD was used to treat in vitro samples of both forms of gramme-positive bacteria. Results led Dr. Blaskovich to believe that CBD worked at levels comparable to the vancomycin and daptomycin prescription antibiotics. He also found that CBD tended to function against resistant bacteria’s gramme-positive strains, which many conventional antibiotics tend to struggle at.
‘In particular, activity against resistant Staphylococcus aureus (MRSA, VISA, VRSA), Streptococcus pneumoniae (MDR) and Enterococcus faecalis (VRE) strains was maintained. Cannabidiol was bactericidal, showed low resistance propensity and was active against MRSA biofilms.’
The team also performed a further analysis using topical CBD to treat mice with a skin infection. Again, although the findings were good, it seemed that CBD did not clear the infection but merely decreased the number of bacterial cells.
Can CBD be turn into antibiotic?
Although it would be easy to applaud this work as a big advance in CBD’s antibacterial capabilities, it is still too early to let go of penicillin.
While it is assumed that the effectiveness of CBD can derive from the way it attacks the biofilm surrounding bacterial cells, the authors remain unsure of the mechanism of action of CBD. They have also been able to point out the shortcomings of the analysis. Dr. Blaskovich emphasised that it is much too early for individuals to start self-treating infections with CBD since the findings are in preliminary stages.
The research was also performed in vitro (outside the human body), so there is a possibility that in clinical trials, we will not get the same outcomes. Many compounds in Petris dishes demonstrated antibacterial efficacy but failed at this crucial point. It is worth noting also that both studies were carried out in partnership with Botanix Pharmaceuticals Ltd., A drug company which specialises in CBD topical products.
Nevertheless, this work may be an essential move forward for CBD and countering antimicrobial resistance. CBD is still displaying a strong safety profile and is not considered dangerous, even in large amounts. Luckily, Dr. Blaskovich and his team intend to continue their work by studying CBD in models of infection in animals. The idea is that they would be able to distinguish which bacterial strains it could what, which it could completely destroy and the exact mechanism of action.
Cibdol.com. 2020. Cibdol – Could CBD Be An Antibiotic?. [online] Available at: <https://www.cibdol.com/blog/815-could-cbd-be-an-antibiotic> [Accessed 9 April 2020].
While more research is needed, a new study indicates that CBD provides capacity for neuroprotection against degenerative diseases, such as Alzheimer’s and Parkinson’s.
In 2003, a patent for the neuroprotective potential of non-psychoactive cannabinoids had been issued to the U.S. Department of Health and Human Services. A federal government branch that classifies marijuana as an illicit substance with with no accepted medical value, has technology rights to CBD’s ability to protect the brain.
“Cannabinoids are considered to have a particular application as neuroprotectants, for example in the limitation of neurological damage after ischemic injuries such as stroke and fracture or in the treatment of neurodegenerative diseases,” states patent No. 6,630,507.
A new study published last month by Korean scientists in the journal Marijuana and Cannabinoid Science attempted dive deeper. Although this patent is owned by the federal government, the scientific community has published mixed results on this phenomenon. Variables such as types of brain cells and experimental environments have resulted in “specific and somewhat conflicting findings,” the researchers wrote, with the goal of knowing whether or not CBD has any ability to shield brain cells from oxidative stress.
The response, it turns out, is yes — there is a possible link between CBD and slowing death of brain cells.
“The use of low concentration CBD has greatly saved the neurons from oxidative stress and established their potential for neuroprotection,” researchers concluded.
Researchers tested what effects differing levels of CBD molecules had on hydrogen peroxide (H2O), or oxidative stress, for the analysis. In neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, and ALS the enzyme is known to be a pathological culprit.
Tested under “in vitro” conditions or in a petri dish, researchers found that CBD’s antioxidant properties supplied hippocampal neurons with a defensive layering induced by oxidative stress from the initiation and development of apoptosis, or cell death.
Researchers, involved, recognised the need for more study, as the brain comprises complex structures and networks that could affect these findings. They added possible avenues of further research regarding CBD administration – That is, whether taking CBD by drinking, eating foods or applying them topically could have an influence on the brain. But the study concluded that CBD does have neuroprotective properties worth investigating further.
Bures, :., 2020. Study Confirms CBD Could Protect Brain Against Neurodegenerative Diseases – The Fresh Toast. [online] The Fresh Toast. Available at: <https://thefreshtoast.com/cannabis/study-confirms-cbd-could-protect-brain-against-neurodegenerative-diseases/> [Accessed 11 March 2020].
Oral hygiene powerhouse Colgate Palmolive joins the ranks of large U.S. companies joining the hemp and CBD market, with one of its soon-to-be brands introducing a line of cannabidiol-containing toothpastes, mouthwash and lip balms.
Hello Products, a New Jersey-based oral care company, launched their CBD range of seven products earlier this week, CosmeticsDesign announced.
In January Colgate reached a deal to purchase the “naturally friendly” name, noting its “strong appeal among younger consumers and across broad segments.”
Hello Products was created in 2012 by Craig Dubitsky, and has products in more than 44,000 U.S. retail outlets.
CBD collection of the business is made up of three toothpastes, two mouthwashes, and two lip balms.
Both include broad spectrum hemp oil and hemp extract from hemp cultivated by affiliate farmers located in the U.S. and were sold in 1,190 Ulta Beauty stores beginning Feb. 1, the company said in a statement.
The purchase of Hello Products was a stock & cash transaction and was expected to close by February 2020 at the latest, Colgate said.
Hemp Industry Daily. (2020). Colgate to acquire brand with new CBD line of toothpaste, mouthwash. [online] Available at: https://hempindustrydaily.com/colgate-to-aquire-brand-with-new-cbd-line-of-toothpaste-mouthwash/ [Accessed 23 Feb. 2020].
The FSA has set a deadline for CBD firms to provide further detail on CBD products and their content. It also advises that vulnerable groups do not take CBD, and that healthy adults consume no more than 70mg a day.
The Food Standards Agency (FSA) is giving the CBD sector a deadline of 31 March 2021 to request legitimate applications for the authorisation of novel products. Those goods which have filed a legitimate application will be allowed to stay on the market after 31 March next year. The authorisation process guarantees that new foods, including on health and material, follow legal standards.
Local authorities impose the law on innovative foods. During this time, they were told that businesses should be able to market their current CBD goods because they are not incorrectly labelled, are not unsafe to eat and do not contain drugs that come under drug law.
However, today the FSA is warning those who are pregnant, breastfeeding or take other medication not to ingest CBD related products. It’s also advised that healthy adults think carefully before taking CBD, not more than 70 mg a day (about 28 drops of 5 percent CBD) is recommended by the FSA except under medical guidance. The latest precautionary advice is based on recent findings from the Toxicity Committee (COT) of the UK.
Food Standards Agency chief executive Emily Miles said:
CBD products are widely available on the high street but are not properly authorised. The CBD industry must provide more information about the safety and contents of these products to the regulator before 31 March 2021, or the products will be taken off the shelves.
Also today, we are advising that CBD could be risky for vulnerable groups, and suggesting an upper limit of 70mg a day for everyone else taking the product.
The actions that we’re taking today are a pragmatic and proportionate step in balancing the protection of public health with consumer choice. It’s now up to industry to supply this information so that the public can be reassured that CBD is safe and what it says it is.
The Chair of the Toxicity Panel, Professor Alan Boobis said:
My committee has reviewed the evidence on CBD food products and found evidence there are potential adverse health effects from the consumption of these products. We are particularly concerned about pregnant or breast-feeding women and people on medication.
We don’t know enough to be sure about such a risk but I am pleased with the sensible and pragmatic approach the FSA is taking. The committee will continue to keep these products under review in the months ahead.
What Is CBD?
- CBD is a chemical found naturally within the cannabis plant, it has been extracted and marketed as a separate CBD product only very recently. CBD extracts can be used in a variety of products including fats, confectionery, baking products and drinks.
- In January 2019 CBD had been verified as a novel food product. Under the novel food regulations, before they can be put on the market, products or food ingredients that do not have a history of use before May 1997 should be tested and approved. Further information on innovative foods can be found on our website.
- The FSA announcement today surrounding CBD extracts occurs in England, Wales and Northern Ireland. Food Standards Scotland covers innovative nutrition laws in Scotland.
- It is up to the FSA to control CBD as a novel substance. This does not include medicines, vapes, therapeutic claim-making products or products that contain controlled drugs such as THC. Where CBD derivatives do contain THC (or other regulated cannabinoids), they are likely to fall under the 1971 Misuse of Drugs Act, and further advice is required from the Home Office, which has issued a factsheet on hemp, CBD and other cannabinoids.
- Those who take medically prescribed CBD or THC will have no effects from this announcement.
The FSA is the Central Competent Authority (CCA) for food safety, but local authorities are responsible for enforcing food legislation on a daily basis. The FSA issues guidance to support consistency in approach, but ultimately it is up to local authorities to make specific enforcement decisions based on the facts and circumstances of the individual cases.
Committee On Toxicity
The Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) is an independent scientific commission providing advice on chemicals toxicity issues to the FSA, the Department of Health and Health Care and other federal departments and agencies.
Food Standards Agency. (2020). Food Standards Agency sets deadline for the CBD industry and provides safety advice to consumers. [online] Available at: https://www.food.gov.uk/news-alerts/news/food-standards-agency-sets-deadline-for-the-cbd-industry-and-provides-safety-advice-to-consumers [Accessed 15 Feb. 2020].
For most athletes, intensive training can lead to certain physical injuries. It can include pains in the body, cuts, fractures and much more. Typical pain relievers and medications, however, are sometimes unsuitable for all. Some drugs are stimulated with side effects such as drowsiness and allergies which are not applicable to athletes who need to be active during the training. A lot of people are asking for athletes about cannabidiol or CBD in search of a better sports recovery. Studies suggest that repeated use of over-the-counter pain relievers can lead to higher risks for the user. Having said that, athletes become more knowledgeable about the cannabidiol’s relieving effects.
People have been using cannabis for decades as a way to treat different conditions, from simple headaches to a more severe disorder. The demand for cannabis is already high, according to experts, until recreational and medical cannabis has become legal in many states and around the world. Apparently there is a lot of confusion about what CBD is and how it can be used as medical relief. Therefore, careful research is still under way to catch up with how people use CBD. And despite the lack of concrete evidence, for many athletes, CBD does appear to effectively relieve pain.
Does CBD Works For Athletes?
In some jurisdictions where cannabis is permissible, competitors are allowed to consume cannabidiol. What is surprising, is that cannabinoids also reside in the blood, which is responsible for modulating neuronal activity. Cannabidiol (CBD) is naturally found in cannabis plants. Science has demonstrated that the nervous system contains two endocannabinoids-2-AG and EAE. This mechanism prevents the production of different neurotransmitters within the body. Of example, if CBD is used to treat a psychiatric condition, it may alleviate hallucinations and breakdowns due to the release of neurotransmitters.
One can’t avoid coping with so much exhaustion and tension as an athlete which leads to more pain and inflammation in the body. The good thing is, CBD will supplement or improve the function of the current endocannabinoid system in the body. Therefore, every preparation offers a tremendous relief.
Checking The Different Benefits That One Can Get From Using CBD!
Many studies have shown that cannabis is effective for relieving pain and can also help athletes reduce stress. CBD can provide an alternative remedy for people suffering from chronic pain and relying on medicines, such as opioids that may affect habits and may even cause more side effects. Further work is however needed to check the pain-relieving effects of CBD oil and other drugs.
Can CBD Be An Viable Alternative To NSAIDs?
Many competitors buy non-steroidal anti-inflammatory medications (NSAIDs), which are over-the-counter. Athletes are normally advised to avoid NSAIDs during lengthy workouts and activities. But even if the exercises and basic routine are short, using NSAIDs regularly can also increase the risk of stroke and heart attack. Several athletes have discovered the CBD can reduce its pain-relieving effects or eliminate their use of NSAIDS for pain associated with minimal side effects in training.
Can CBD Reduce Inflammation?
For most athletes, a small amount of inflammation can spark positive adaptation to the training. However it’s not a good thing to suffer from too much inflammation. It may impact the player’s overall performance during preparation, or even worse, during the game itself. A bit of inflammation can be useful for athletes and can help stimulate positive adaptations to the training. But too much of it can quickly hinder rapid recovery, affecting results.
Can CBD Improve The Quality Of Sleep?
One of the most effective ways a person can do well in competition is to have a longer and better night’s sleep. Although preparation can be somehow unpleasant, athletes who ingest CBD have been seen to be performing better during the exercise.
Can It Be Used To Relieve Stress And Anxiety?
Long hours of exercise and peer pressure can be overwhelming in some way. There are times where one want to sit all day on the couch or bed, and one might say that they want to give up. Good thing cannabis, in its medical form, can be used as an outstanding treatment to get rid of the debilitating symptoms of fear in a person.
Can CBD Provide Various Relaxing Effects
Isn’t it good to feel comfortable and relaxed after a long day of tiring routines? Chances are one won’t be able to go to sleep early because of ones disturbed minds and tired body. But one does not have to worry now, because one can now search for different cannabis-infused products to help you get through for another training set.
Despite CBD’s negative effects, there’s no question why more and more people want it as a treatment for any discomfort. For starters, athletes are a part of the high percentage of people benefiting from CBD. Yeah, with CBD goods on hands, there’s no path to an overwhelming workout day!
Uren, T. (2020). Discover How Athletes Can Benefit from CBD. [online] Pro Sports Extra |. Available at: https://prosportsextra.com/discover-how-athletes-can-benefit-from-cbd/ [Accessed 8 Feb. 2020].
CBD Works are proud to announce that we are a sponsor of Lasswade Rugby Club is a rugby union club based in Bonnyrigg, Midlothian, Scotland. Established in 1921, the club plays at Hawthornden in Lasswade parish and competes in Scottish National League Division Two, the third tier of Scottish club rugby.
As one of the country’s leading suppler’s of CBD related products we’re keen to give back to the communities in which we live and work. We feel it’s important to support local initiatives where our business are based and where the majority of our clients are.
The opportunity to get involved in supporting the club was a real pleasure. Any sports team is only ever as good as it’s players, and we feel the same can be said in Business. Our sponsorship reflect our core values to be challenging, caring, tenacious, responsive and trusted – and our understanding that corporate social responsibility is something that all involved can share in.
As we continue to transform our own business and enjoy rapid growth with our customers, we felt that we would like to get more involved and help Lasswade RFC reach their goals and to also grow.